Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as a function of treatment plan parametersVisa övriga samt affilieringar
2022 (Engelska)Ingår i: Frontiers in Oncology, E-ISSN 2234-943X, Vol. 12, artikel-id 903537
Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
Out-of-field patient doses in proton therapy are dominated by neutrons. Currently, they are not taken into account by treatment planning systems. There is an increasing need to include out-of-field doses in the dose calculation, especially when treating children, pregnant patients, and patients with implants. In response to this demand, this work presents the first steps towards a tool for the prediction of out-of-field neutron doses in pencil beam scanning proton therapy facilities. As a first step, a general Monte Carlo radiation transport model for simulation of out-of-field neutron doses was set up and successfully verified by comparison of simulated and measured ambient neutron dose equivalent and neutron fluence energy spectra around a solid water phantom irradiated with a variation of different treatment plan parameters. Simulations with the verified model enabled a detailed study of the variation of the neutron ambient dose equivalent with field size, range, modulation width, use of a range shifter, and position inside the treatment room. For future work, it is planned to use this verified model to simulate out-of-field neutron doses inside the phantom and to verify the simulation results by comparison with previous in-phantom measurement campaigns. Eventually, these verified simulations will be used to build a library and a corresponding tool to allow assessment of out-of-field neutron doses at pencil beam scanning proton therapy facilities.
Ort, förlag, år, upplaga, sidor
Frontiers Media SA , 2022. Vol. 12, artikel-id 903537
Nyckelord [en]
Proton therapy, Pencil beam scanned proton therapy, Neutron doses, Monte Carlo simulations, Out-of-field neutron doses in radiation therapy, Neutron measurements
Nationell ämneskategori
Radiologi och bildbehandling Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:kth:diva-322220DOI: 10.3389/fonc.2022.903537ISI: 000884350700001PubMedID: 36158693Scopus ID: 2-s2.0-85136947416OAI: oai:DiVA.org:kth-322220DiVA, id: diva2:1716286
Anmärkning
QC 20221205
2022-12-052022-12-052024-01-17Bibliografiskt granskad