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3 D-printed micrograters for sampling of the blood vessel wall
KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Micro and Nanosystems. Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..ORCID iD: 0000-0003-1235-9099
KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering.ORCID iD: 0000-0002-2230-5097
KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Micro and Nanosystems.ORCID iD: 0000-0001-8248-6670
KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Micro and Nanosystems.ORCID iD: 0000-0001-9552-4234
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2021 (English)In: 2021 34th IEEE international conference on micro electro mechanical systems (MEMS 2021), Institute of Electrical and Electronics Engineers (IEEE) , 2021, p. 548-550Conference paper, Published paper (Refereed)
Abstract [en]

Endothelial cells lining blood vessels have phenotypic variations that indicate the health/disease status for a variety of conditions, including atherosclerosis and hypertension. Current sampling strategies lead to a high variation in the sampled amount, and we are not aware of sampling tools specifically targeting endothelial cells. Here, we present a new type of endovascular catheter for sampling of the blood vessel wall. The catheter is a 380 mu m nitinol tube over which 3D printed graters are threaded. The catheter is designed to be non-invasive during the axial motion and to interact with the blood vessel wall when rotated. Initial results indicate successful in-vivo sampling - with minimal blood contamination - of the wall of blood vessels less than 0.5 mm in diameter.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE) , 2021. p. 548-550
Series
Proceedings IEEE Micro Electro Mechanical Systems, ISSN 1084-6999
Keywords [en]
Biopsy, catheter, 3D-printed, minimally invasive, blood vessel wall
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-298960DOI: 10.1109/MEMS51782.2021.9375314ISI: 000667731600134Scopus ID: 2-s2.0-85103441279OAI: oai:DiVA.org:kth-298960DiVA, id: diva2:1581846
Conference
34th IEEE International Conference on Micro Electro Mechanical Systems (MEMS), JAN 25-29, 2021, ELECTR NETWORK
Note

QC 20210726

Available from: 2021-07-26 Created: 2021-07-26 Last updated: 2022-06-25Bibliographically approved

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Sandell, MikaelJonsson, Stefanvan der Wijngaart, WouterStemme, GöranRoxhed, Niclas

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Citation style
  • apa
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