To date, blood plasma analytes are frequently being used as accepted biomarkers for disease [1]. In order to efficiently detect these analytes, the sample is preferred to be completely free of cells. The lack of a generic integrated blood plasma separation technique has long been one of the obstructions for the large-scale adaptation of microfluidic-based sample-to-answer diagnostic assays, especially for larger sample volumes. Here, we present a robust, scalable, low-cost and secure technology that automatically measures, and dispenses sequentially and proportionally a given volume of blood plasma inside a centrifuge tube.