The frequent occurrences of bridge fires and the substantial disruptions and direct/indirect economic losses resulting from these events highlight the immediate need for effective fire-safety-oriented design of new bridges and retrofit approaches for vulnerable existing bridges. In this Perspective, we discuss why a holistic engineering approach integrating innovative fire analysis methods and structural design/retrofit strategies into multi-hazard and future-oriented risk modeling frameworks represents the way forward to more sustainable and resilient infrastructure in an uncertain and rapidly changing built environment. Bridge fires cause significant disruptions and economic losses in modern society, yet fire hazards are still often ignored or oversimplified in bridge design. This Perspective emphasizes the need for more holistic and comprehensive fire-safety design when retrofitting or designing new bridges.