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Competition and cooperation of assembly sequences in recurrent neural networks
Institute for Neural Computation, Ruhr University Bochum, Bochum, Germany; Centre for Integrative Neuroplasticity, University of Oslo, Oslo, Norway; Goethe University Frankfurt, Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Medical Center Frankfurt, Frankfurt, Germany.ORCID iD: 0000-0003-3853-0608
Centre for Integrative Neuroplasticity, University of Oslo, Oslo, Norway; Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Göttingen, Germany.
Department of Computer Science, School of Mathematics, Statistics and Computer Science, College of Science, University of Tehran, Tehran, Iran.
Department of Computer Science, School of Mathematics, Statistics and Computer Science, College of Science, University of Tehran, Tehran, Iran.
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2025 (English)In: PloS Computational Biology, ISSN 1553-734X, E-ISSN 1553-7358, Vol. 21, no 9, article id 1013403Article in journal (Refereed) Published
Abstract [en]

Neural activity sequences are ubiquitous in the brain and play pivotal roles in functions such as long-term memory formation and motor control. While conditions for storing and reactivating individual sequences have been thoroughly characterized, it remains unclear how multiple sequences may interact when activated simultaneously in recurrent neural networks. This question is especially relevant for weak sequences, comprised of fewer neurons, competing against strong sequences. Using a non-linear rate -based and a spiking model with discrete, pre-configured assemblies, we demonstrate that weak sequences can compensate for their competitive disadvantage either by increasing excitatory connections between subsequent assemblies or by cooperating with other co-active sequences. Further, our models suggest that such cooperation can negatively affect sequence speed unless subsequently active assemblies are paired. Our analysis characterizes the conditions for successful sequence progression in isolated, competing, and cooperating assembly sequences, and identifies the distinct contributions of recurrent and feed-forward projections. This proof-of-principle study shows how even disadvantaged sequences can be prioritized for reactivation, a process which has recently been implicated in hippocampal memory processing.

Place, publisher, year, edition, pages
Public Library of Science (PLoS) , 2025. Vol. 21, no 9, article id 1013403
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Neurology Medical Informatics Engineering
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URN: urn:nbn:se:kth:diva-371986DOI: 10.1371/journal.pcbi.1013403ISI: 001570225000007PubMedID: 40939008Scopus ID: 2-s2.0-105017444805OAI: oai:DiVA.org:kth-371986DiVA, id: diva2:2009465
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QC 20251028

Available from: 2025-10-28 Created: 2025-10-28 Last updated: 2025-10-28Bibliographically approved

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Kumar, Arvind

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