Indirect evaporative chiller (IEC) can produce chilled water below the wet-bulb temperature of outdoor air. To evaluate the potential of applying indirect evaporative chillers for covering the high indoor sensible cooling loads in commercial buildings of Northern European countries, a case study based on a real commercial building in Stockholm was carried out assuming renovation of the existing air-conditioning system by replacing district cooling with an indirect evaporative chiller as cooling source. Numerical models were built for the indirect evaporative chiller as well as for the entire space cooling system, and techno-economic performance evaluation as well as sensitivity analyses were conducted with a validated numerical model to comprehensively evaluate renovation benefits. The simulation results show that, an indirect evaporative chiller fulfilling 80 % of the total sensible cooling load of the design outdoor condition with a dry-bulb outdoor air temperature of 26 °C and a relative humidity of 45 %, can produce chilled water below the wet-bulb outdoor air temperature when the relative humidity is lower than 0.4 for hours in July of year 2015 and 2018. Sensitivity analyses show that reducing the supply air flow rate of the ventilation system from the default setpoint of 1.2 L/(m2·s) to the minimum hygienically required level of 0.35 L/(m2·s) would double the seasonal energy efficiency rating of the air-conditioning system from 6.3 to 12.8. Compared to the original district cooling-based system, the operational expenditure of the renovated system can be saved for optimally 54 k SEK, justifying a capital expenditure of 588 k SEK assuming operation of 15 years. The case study shows that indirect evaporative chiller can potentially be applied for commercial buildings under the and climatic and market context of Sweden, providing an alternative cooling solution for similar applications.