Studies in the agro-industry sector have shown the importance to evaluate the feasibility of an IBLC (a multi-product transformation plant). This paper develops a model to simulate the performance of an IBLC in Spain, using a combined approach: AHP, TOPSIS, and a hybrid simulation model. Results show that profits can be incremented by about 55.7% and environmental emissions of KgCO2e per tonne of bio-commodity produced, reduced by 24.2%. The scientific contribution covers the development of a simulation model that dynamically select suppliers based on a combination of social, environmental, and economic criteria. In addition, the model can be used to evaluate the economic and environmental feasibility of the IBLC by integrating the suppliers selection with the operations of a multi-product transformation plant.