The PION code has been integrated into the European Transport Solver (ETS) transport workflow, and we present the first application to model Ion Cyclotron Resonance Frequency (ICRF) heating scenarios in the next-step fusion reactor ITER. We present results of predictive, self-consistent and time-dependent simulations where the resonant ion concentration is varied to study its effects on the performance, with a special emphasis on the resulting bulk ion heating and thermal ion temperature. We focus on two ICRF heating schemes, i.e., fundamental H minority heating in a 4He plasma at 2.65 T/7.5 MA and a three-ion ICRF scheme consisting of fundamental 3He heating in a H-4He plasma at 3.3 T/ 8.8 MA. The H minority heating scenario is found to result in strong absorption by resonant H ions as compared to competing absorption mechanisms and dominant background electron heating for H concentrations up to 10%. The highest H absorption of ∼80% of the applied ICRF power and highest ion temperature of ∼15 keV are obtained with an H concentration of 10%. For the three-ion scheme in 85%:15% H:4He plasma, PION+ETS predicts 3He absorption in the range of 21–65% for 3He concentrations in the range of 0.01–0.20%, with the highest 3He absorption at a 3He concentration of 0.20%.