Lately, the marriage of elastic silicone rubbers and electronics has given birth to a radically new class of electronic devices and systems, so-called silicone-based soft electronics. Based on this new concept, electronics can nowadays be built in soft, rubbery, biological formats, for enabling numerous new applications, in which conventional rigid electronics are impossible to use. This chapter briefly reviews recent research advances in the emerging field of soft electronics. Various strategies for realizing elastic electronics are addressed, and the focus of this chapter lies in microfluidic approaches. Recently reported elastomeric soft electronic devices using microfluidic techniques, e.g., elastic passive antennas, a soft RF radiation sensor, as well as a reversibly stretchable, body-worn wireless strain sensor, are presented and analyzed in detail. Lastly, future perspectives and outlook for silicone-based soft electronics are discussed.