During the Extreme Universe Space Observatory on a Super Pressure Balloon 2 (EUSO-SPB2) mission, we planned Target of Opportunity (ToO) operations to follow up on possible sources of ≳ 10 PeV neutrinos. The original plan before flight was to point the onboard Cherenkov Telescope (CT) to catch the source’s path on the sky just below Earth’s horizon. By using the Earth as a tau-neutrino to tau-lepton converter, the CT would then be able to look for optical extensive air shower signals induced by tau-lepton decays in the atmosphere. The CT had a field of view of 6.4◦ vertical × 12.8◦ horizontal. Possible neutrino source candidates include gamma ray bursts, tidal disruption events and other bursting or flaring sources. In addition, follow-ups of binary neutron star mergers would have been possible after the start of the O4 observation run from LIGO-Virgo-KAGRA. The resulting exposure is modeled using the NuSpaceSim framework in ToO mode. With the launch of the EUSO-SPB2 payload on the 13th May 2023, this summarizes the ToO program status and preliminary data, as available.