kth.sePublications KTH
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Spatio-temporal activity patterns induced by triadic interactions in an in silico neural medium
Institute ‘Carlos I’ for Theoretical and Computational Physics, and Department of Electromagnetism and Physics of the Matter, University of Granada, E-18071 Granada, Spain.
Nordita SU.
Institute ‘Carlos I’ for Theoretical and Computational Physics, and Department of Electromagnetism and Physics of the Matter, University of Granada, E-18071 Granada, Spain.
2025 (English)In: Journal of Physics: Complexity, E-ISSN 2632-072X, Vol. 6, no 1, article id 015017Article in journal (Refereed) Published
Abstract [en]

Triadic interactions in the brain are general mechanisms by which a node, e.g. a neuron or a glia cell such as the astrocyte, can regulate directly the link, e.g. synapse between other two nodes. The regulation takes place in a familiar way by either depressing or facilitating synaptic transmission. Such interactions are ubiquitous in neural systems, accounting both for axo-axonic and tripartite synapses mediated by astrocytes, for instance, and have been related to neuronal and synaptic processes at different time-scales, including short- and long-term synaptic plasticity. In the field of network science, triadic interactions have been shown to produce complex spatio-temporal patterns of connectivity. Here, we investigate the emergent behavior of an in silico neural medium constituted by a population of leaky integrate-and-fire neurons with triadic interactions. We observe that, depending on relevant parameters defining triadic interactions, different activity patterns emerge. These include (i) a silent phase, (ii) a low-activity phase in which complex spatio-temporal patterns of low neuronal firing rate emerge that propagate through the medium, (iii) a high-activity phase characterized by complex spatio-temporal patterns of high neuronal firing rate that propagate through the neural medium as waves of high firing activity over a bulk of low activity neurons, and (iv) a pseudo-blinking phase in which the neural medium switches between high and low activity states. Here we analyze in depth the features of such patterns and relate our findings to the recently proposed model of triadic percolation.

Place, publisher, year, edition, pages
IOP Publishing , 2025. Vol. 6, no 1, article id 015017
Keywords [en]
activity-dependent synaptic regulation, axo-axonic synapses, triadic interactions
National Category
Neurosciences Bioinformatics (Computational Biology)
Identifiers
URN: urn:nbn:se:kth:diva-362034DOI: 10.1088/2632-072X/adbf5eScopus ID: 2-s2.0-105000750291OAI: oai:DiVA.org:kth-362034DiVA, id: diva2:1949707
Note

QC 20250407

Available from: 2025-04-03 Created: 2025-04-03 Last updated: 2025-04-07Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus
NeurosciencesBioinformatics (Computational Biology)

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 28 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf