In order to bolster the next generation of wireless networks, there has been a great deal of interest in nonterrestrial networks (NTN), including satellites, high altitude platform stations (HAPS), and uncrewed aerial vehicles (UAV). To unlock their full potential, these platforms can integrate advanced technologies such as reconfigurable intelligent surfaces (RIS) and next-generation multiple access (NGMA). However, in practical applications, transceivers often suffer from radio frequency (RF) impairments, which limit system performance. In this regard, this paper explores the potential of multi-layer NTN architecture to mitigate path propagation loss and improve network performance under hardware impairment limitations. First, we present current research activities in the NTN frame-work, including RIS, multiple access technologies, and hardware impairments. Next, we introduce a multi-layer NTN architecture with hardware limitations. This architecture includes HAPS super-macro base stations (HAPS-SMBS), UAVs-equipped with passive or active transmissive RIS-, and NGMA techniques, like non-orthogonal multiple access (NOMA), as the multiple access techniques to serve terrestrial devices. Additionally, we present and discuss potential use cases of the proposed multi-layer architecture considering hardware impairments. The multi-layer NTN architecture combined with advanced technologies, such as RIS and NGMA, demonstrates promising results; however, the performance degradation is attributed to RF impairments. Finally, we identify future research directions, including RF impairment mitigation, UAV power management, and antenna designs.