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Recent perspective of chitosan in wound healing approaches – A review
Department of Mechanical and Industrial Engineering, Qatar University, Doha 2713, Qatar; Biomedical Research Center, Qatar University, Doha 2713, Qatar.
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Polymer Technology.ORCID iD: 0000-0002-7790-8987
Oral and Maxillofacial Surgery Unit, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kota Bharu, Kelantan 16150, Malaysia; Oral and Maxillofacial Surgery Unit, Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kota Bharu, Kelantan 16150, Malaysia.
Institute for Engineering in Medicine, Health, & Human Performance (EnMed), Batten College of Engineering and Technology, Old Dominion University, Norfolk, VA 23529, USA.
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2025 (English)In: Materials Today Communications, ISSN 2352-4928, Vol. 47, article id 113288Article, review/survey (Refereed) Published
Abstract [en]

Wound healing is a complex process depending on several interrelated elements. Wound healing and management have to be based on an awareness of normal tissue regeneration and the elements affecting this process. The perfect wound dressing should be reasonably priced and cause the person the least possible pain. Because of its cytocompatibility, biodegradability, non-carcinogenic, and antibacterial qualities, chitosan is among the most often investigated biopolymers for use in wound healing. Furthermore, chitosan and its derivatives attract a lot of attention because of their easy processability in wound dressings and their capacity to hasten the healing process. These qualities make chitosan-based materials rather flexible and appealing for use as wound dressings. Moreover, secondary metabolic byproducts could be antifungal and antibacterial agents, thus accelerating the healing process. A thorough literature review on chitosan-based dressing for wounds is still lacking. We have compiled the features of skin physiology, chitosan, and the phases of wound healing. We have discussed the importance of dressing materials based on chitosan, including the delivery mechanism. We have finally addressed the relevance of chitosan, its future prospects, and its constraints, as well as other ideas for development in wound healing.

Place, publisher, year, edition, pages
Elsevier BV , 2025. Vol. 47, article id 113288
Keywords [en]
Biocompatible, Biopolymer, Chitosan, Dressing materials, Drug delivery, Wound healing
National Category
Medical Materials Textile, Rubber and Polymeric Materials
Identifiers
URN: urn:nbn:se:kth:diva-368897DOI: 10.1016/j.mtcomm.2025.113288ISI: 001533247500001Scopus ID: 2-s2.0-105009919289OAI: oai:DiVA.org:kth-368897DiVA, id: diva2:1991182
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QC 20250822

Available from: 2025-08-22 Created: 2025-08-22 Last updated: 2025-10-24Bibliographically approved

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Hakkarainen, Minna

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