Configure-to-Order (CTO) assembly systems are becoming pivotal in meeting the rising demand for mass customization. However, enabling rapid and cost-effective system reconfiguration remains a major challenge in manufacturing. Despite the flexibility of general-purpose machines, fixture design introduces significant bottlenecks, often requiring extensive manual effort to access, organize, and interpret fragmented or incomplete data. This leads to inefficient design pipelines that can compromise product functionality and result in costly redesign iterations, even when using advanced Computer-Aided Fixture Design (CAFD) tools. Although the Model-Based Definition (MBD) paradigm offers a promising response to these information-related challenges, its adoption within the CAFD domain remains limited. This work aims to support the broader adoption of MBD in this field through a multi-level contribution. First, a structured literature review identifies the essential semantic information required in an MBD dataset tailored to CAFD. Second, this content is structured in a machine-readable form using the ISO standard STEP AP242. Third, an MBD-driven CAFD framework is proposed. Finally, a proof-of-concept CAFD tool is developed by integrating established methodologies with commercial software to automate non-value-added tasks, such as configuring Computer-Aided Technologies (CAx). The results demonstrate the potential of this approach to streamline CAFD processes and establish a fully connected digital thread.