The 2025 Machine Learning for X-ray and Neutron Scattering, MLXN25, virtual event was held on April 15, 2025, as a continuous 24-h global event, uniting over 300 registered participants from 18 countries and 20 user facilities to discuss how machine learning (ML) is transforming X-ray and neutron science. This year’s program offered a sweeping view of emerging ML methodologies across data processing, simulation, autonomous control and instrumentation development. The event featured talks, tutorials, open discussions and several live demonstrations. With contributions from academia, government laboratories and industry, MLXN25 exemplified a vibrant, global research community pushing the boundaries of scientific discovery through artificial intelligence (AI).